Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.32 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382155 | 0.98 | CHRM3 (0.33) | CHRM3CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL7199231 | 0.96 | CHRM3 (0.32) | CHRM3CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL6064899 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL7196141 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL7630700 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL1538415 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL7630694 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL6064957 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL6064407 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL6295594 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992035-B2 | Metallocenes, polymerization catalyst systems, their preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 2006-01-31 | — | — | US | disclosed |
| US-20030092925-A1 | Metallocenes, polymerization catalyst systems, their preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 2003-05-15 | — | — | US | disclosed |
| US-6509427-B1 | Cocatalyst and Group 4B, 5, or 6 metal complex comprising unsaturated compound with cyclopentadienyl, indenyl, or fluorenyl substituent; addition polymerization of olefins | PHILLIPS PETROLEUM COMPANY | 2003-01-21 | — | — | US | disclosed |
| US-6187880-B1 | USING SOLID CATALYST SYSTEM PREPARED BY COMBINING A METALLOCENE WITH A SOLUTION OF AN ORGANOALUMINOXANE COCATALYST AND CONDUCTING PREPOLYMERIZATION TO PRODUCE A PREPOLYMERIZED SOLID | PHILLIPS PETROLEUM COMPANY | 2001-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092925-A1 | Metallocenes, polymerization catalyst systems, their preparation, and use | WASF2, WEE2, NOTUM | CHRM3 1108/4885CHRM2 724/4885CHRM1 741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.