Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 15/20 | 0.50 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6066295 | 0.90 | ROS1 (0.53) | ROS1RPS6KB1TRPV1GLSDGAT2 | |
| SCHEMBL4026467 | 0.82 | ROS1 (0.73) | ROS1RPS6KB1TRPV1DGAT2 | |
| SCHEMBL4020324 | 0.79 | EPHX2 (0.60) | ROS1RPS6KB1TRPV1GLS | |
| SCHEMBL4030337 | 0.78 | TRPV1 (0.69) | ROS1RPS6KB1TRPV1GLSDGAT2 | |
| SCHEMBL4021187 | 0.77 | TRPV1 (0.57) | ROS1RPS6KB1TRPV1GLSDGAT2 | |
| SCHEMBL4021335 | 0.76 | ROS1 (0.55) | ROS1RPS6KB1TRPV1DGAT2 | |
| SCHEMBL4022317 | 0.72 | ROS1 (0.61) | ROS1RPS6KB1TRPV1GLS | |
| SCHEMBL4025364 | 0.72 | TRPV1 (0.64) | ROS1RPS6KB1TRPV1GLS | |
| SCHEMBL6583327 | 0.72 | ROS1 (0.55) | ROS1RPS6KB1TRPV1GLS | |
| SCHEMBL4022175 | 0.72 | ROS1 (0.73) | ROS1RPS6KB1TRPV1GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660455-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005016890-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2005-02-24 | — | — | WO | disclosed |