Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROS1 | P08922 | 1/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587146 | 0.94 | ROS1 (0.53) | ROS1RPS6KB1TRPV1GLSKDM4E | |
| SCHEMBL4030518 | 0.91 | ROS1 (0.64) | ROS1RPS6KB1TRPV1GLSKDM4E | |
| SCHEMBL4030337 | 0.85 | TRPV1 (0.69) | ROS1RPS6KB1TRPV1PTPN1GLS | |
| SCHEMBL6584430 | 0.83 | TRPV1 (0.74) | TRPV1 | |
| SCHEMBL4019570 | 0.80 | ROS1 (0.69) | ROS1RPS6KB1TRPV1GLSKDM4E | |
| SCHEMBL4025364 | 0.80 | TRPV1 (0.64) | ROS1RPS6KB1TRPV1PTPN1GLS | |
| SCHEMBL5391279 | 0.79 | ROS1 (0.81) | ROS1RPS6KB1TRPV1PTPN1GLS | |
| SCHEMBL4021307 | 0.79 | ROS1 (0.63) | ROS1RPS6KB1TRPV1PTPN1GLS | |
| SCHEMBL4023632 | 0.79 | ROS1 (0.57) | ROS1RPS6KB1TRPV1GLSKDM4E | |
| SCHEMBL4023210 | 0.78 | TRPV1 (0.69) | ROS1RPS6KB1TRPV1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | Abbott Laboratories (US) | 2004-11-24 | — | — | EP | claimed |
| WO-2003070247-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2003-08-28 | — | — | WO | claimed |