Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288405 | 0.91 | AR (0.42) | ARMEN1KMT2AMAPTRAB9A | |
| SCHEMBL4373016 | 0.86 | MAP2K1 (0.50) | MEN1KMT2ASMN1; SMN2TP53RAB9A | |
| SCHEMBL8289330 | 0.86 | KDM4E (0.48) | MEN1KMT2ASMN1; SMN2MAPTHRH2 | |
| SCHEMBL4375337 | 0.86 | KMT2A (0.40) | ARMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL4558565 | 0.85 | MEN1 (0.48) | MEN1KMT2AMAPTGAA | |
| SCHEMBL8287320 | 0.84 | SLC6A2 (0.46) | ARMEN1KMT2AMAPTRAB9A | |
| SCHEMBL4540892 | 0.83 | GPR55 (0.43) | MEN1KMT2AMAPT | |
| SCHEMBL4381278 | 0.82 | AR (0.39) | ARKMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL4372519 | 0.81 | HRH2 (0.46) | ARKMT2ASMN1; SMN2HRH2HRH1 | |
| SCHEMBL4562563 | 0.81 | HRH2 (0.42) | MEN1KMT2AHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |