Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | USP10 | Q14694 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288405 | 0.82 | AR (0.42) | MAP2K1KDM4EGPR55L3MBTL1HTT | |
| SCHEMBL4373016 | 0.82 | MAP2K1 (0.50) | MAP2K1KDM4EGPR55L3MBTL1HTT | |
| SCHEMBL4375337 | 0.81 | KMT2A (0.40) | MAP2K1KDM4EGPR55L3MBTL1HTT | |
| SCHEMBL6065449 | 0.79 | AR (0.51) | KMT2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL4372519 | 0.79 | HRH2 (0.46) | KDM4EALDH1A1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL4562563 | 0.77 | HRH2 (0.42) | MAP2K1KDM4EGPR55L3MBTL1HTT | |
| SCHEMBL4470142 | 0.76 | KDM4E (0.45) | MAP2K1KDM4EGPR55L3MBTL1HTT | |
| SCHEMBL8289330 | 0.74 | KDM4E (0.48) | MAP2K1KDM4EGPR55L3MBTL1HTT | |
| SCHEMBL4381278 | 0.73 | AR (0.39) | KDM4EALDH1A1KMT2ASMN1; SMN2USP10 | |
| SCHEMBL8288366 | 0.73 | KDM4E (0.53) | KDM4EGPR55L3MBTL1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |