Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zalcitabine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLG | P54098 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.51 |
| ▸ | ALB | P02768 | 3/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.51 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.46 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.46 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zalcitabine SCHEMBL4969964 | 0.96 | POLG (0.59) | POLGPOLBABL1RIN1LMNA | |
| Zalcitabine SCHEMBL211115 | 0.91 | ABL1 (0.57) | POLGPOLBABL1RIN1LMNA | |
| Zalcitabine SCHEMBL285163 | 0.91 | ABL1 (0.57) | POLGPOLBABL1RIN1LMNA | |
| Zalcitabine SCHEMBL6913582 | 0.89 | ABL1 (0.55) | POLGPOLBABL1RIN1LMNA | |
| Zalcitabine SCHEMBL8094882 | 0.89 | LMNA (0.62) | POLGPOLBABL1RIN1LMNA | |
| Zalcitabine SCHEMBL12149465 | 0.89 | LMNA (0.62) | POLGPOLBABL1RIN1LMNA | |
| Zalcitabine SCHEMBL3715526 | 0.89 | LMNA (0.62) | POLGPOLBABL1RIN1LMNA | |
| Zalcitabine SCHEMBL598496 | 0.89 | LMNA (0.62) | POLGPOLBABL1RIN1LMNA | |
| Zalcitabine SCHEMBL21100417 | 0.89 | LMNA (0.62) | POLGPOLBABL1RIN1LMNA | |
| Zalcitabine SCHEMBL3235525 | 0.89 | LMNA (0.62) | POLGPOLBABL1RIN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006003638-A2 | NOVEL METHOD FOR LABELING NUCLEIC ACID IN A SEQUENCE-SPECIFIC MANNER, AND METHOD FOR DETECTING NUCLEIC ACID USING THE SAME | NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES (JP) | 2006-01-12 | — | — | WO | disclosed |