Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 11/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068241 | 0.84 | ABL1 (0.64) | ABL1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL6067860 | 0.79 | ABL1 (0.65) | PIK3CDABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6068149 | 0.78 | ABL1 (0.60) | PIK3CDABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14189671 | 0.78 | ABL1 (0.70) | PIK3CDABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6068165 | 0.77 | ABL1 (0.63) | PIK3CDABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6068323 | 0.76 | ABL1 (0.71) | ABL1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL6067835 | 0.76 | ABL1 (0.71) | PIK3CDABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6067997 | 0.75 | DYRK1A (0.71) | PIK3CDABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6068168 | 0.74 | ABL1 (0.71) | PIK3CDABL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1303393 | 0.74 | RAB9A (0.69) | PIK3CDABL1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091227-B2 | Benzothiazole derivatives | ABBOTT GMBH & CO. KG (DE) | 2006-08-15 | — | — | US | disclosed |
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |