Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 3/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29408543 | 1.00 | PDE5A (0.58) | PDE5ATP53ALDH1A1MAPTKDM4E | |
| SCHEMBL2696718 | 0.95 | PDE5A (0.52) | PDE5ATP53ALDH1A1MAPTKDM4E | |
| SCHEMBL28565216 | 0.89 | PDE5A (0.73) | PDE5ATP53ALDH1A1MAPTKDM4E | |
| SCHEMBL29408541 | 0.89 | PDE5A (0.73) | PDE5ATP53ALDH1A1MAPTKDM4E | |
| SCHEMBL6068425 | 0.88 | PDE5A (0.57) | PDE5ATP53ALDH1A1MAPTKDM4E | |
| SCHEMBL29408493 | 0.88 | PDE5A (0.57) | PDE5ATP53ALDH1A1MAPTKDM4E | |
| SCHEMBL2680815 | 0.87 | PDE5A (0.73) | PDE5ATP53ALDH1A1MAPTKDM4E | |
| SCHEMBL29408511 | 0.86 | PDE5A (0.69) | PDE5ATP53ALDH1A1MAPTKDM4E | |
| SCHEMBL6068350 | 0.86 | PDE5A (0.69) | PDE5ATP53ALDH1A1MAPTKDM4E | |
| SCHEMBL6068408 | 0.86 | PDE5A (0.60) | PDE5ATP53ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087614-B2 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-08-08 | — | — | US | disclosed |