Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29408493 | 1.00 | PDE5A (0.57) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL289912 | 0.92 | PDE5A (0.46) | PDE5AALDH1A1LMNARAB9ADHODH | |
| SCHEMBL29408543 | 0.88 | PDE5A (0.58) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL6068348 | 0.88 | PDE5A (0.58) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL6068350 | 0.88 | PDE5A (0.69) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL29408511 | 0.88 | PDE5A (0.69) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL29408541 | 0.88 | PDE5A (0.73) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL28565216 | 0.88 | PDE5A (0.73) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL6068408 | 0.87 | PDE5A (0.60) | PDE5ATP53MAPTALDH1A1KDM4E | |
| SCHEMBL29408545 | 0.87 | PDE5A (0.60) | PDE5ATP53MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114984229-A | Treatment of addiction and impulse control disorders using PDE7 inhibitors | 奥默罗斯公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-112168972-A | Treatment of addiction and impulse control disorders using PDE7 inhibitors | 奥默罗斯公司 | 2021-01-05 | — | — | CN | disclosed |
| US-7087614-B2 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-08-08 | — | — | US | disclosed |