Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28572874 | 0.87 | PDE5A (0.77) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL29408551 | 0.87 | PDE5A (0.77) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL6068556 | 0.84 | PDE5A (0.66) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL6068488 | 0.78 | PDE5A (0.54) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL290775 | 0.78 | PDE5A (0.80) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL29408550 | 0.78 | PDE5A (0.80) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL28565209 | 0.78 | PDE5A (0.55) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL29408484 | 0.78 | PDE5A (0.55) | PDE5AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL291345 | 0.77 | PDE5A (0.62) | PDE5AALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL29408508 | 0.76 | PDE5A (0.74) | PDE5AALDH1A1MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087614-B2 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-08-08 | — | — | US | disclosed |