Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289823 | 0.86 | PDE5A (0.58) | PDE5APDE2APDE3BPDE3AACHE | |
| SCHEMBL290933 | 0.85 | PDE5A (0.54) | PDE5APDE2APDE3BPDE3AACHE | |
| SCHEMBL290275 | 0.84 | PDE5A (0.57) | PDE5APDE2APDE3BPDE3AACHE | |
| SCHEMBL6068433 | 0.83 | PDE5A (0.58) | PDE5AALDH1A1MAPTTSHRKDM4E | |
| SCHEMBL291065 | 0.83 | PDE5A (0.58) | PDE5APDE2APDE3BPDE3AACHE | |
| SCHEMBL26647635 | 0.83 | PDE5A (0.62) | PDE5APDE2APDE3BPDE3A | |
| SCHEMBL291323 | 0.82 | PDE5A (0.56) | PDE5APDE2APDE3BPDE3AACHE | |
| SCHEMBL291180 | 0.81 | PDE5A (0.54) | PDE5AALKIGF1R | |
| SCHEMBL291049 | 0.81 | PDE5A (0.54) | PDE5AALKIGF1R | |
| SCHEMBL291168 | 0.79 | PDE5A (0.52) | PDE5APDE2APDE3BPDE3AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087614-B2 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-08-08 | — | — | US | disclosed |