Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | MGMT | P16455 | 1/20 | 0.45 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TLR4 | O00206 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793324 | 0.87 | S1PR4 (0.54) | S1PR4ALDH1A1KMT2AAPOBEC3AHTT | |
| SCHEMBL29780767 | 0.84 | MAPT (0.58) | S1PR4ALDH1A1KMT2AAPOBEC3AHTT | |
| SCHEMBL30354912 | 0.84 | ALDH1A1 (0.59) | ALDH1A1KMT2AAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL30218362 | 0.84 | MAPT (0.58) | S1PR4ALDH1A1KMT2AAPOBEC3AHTT | |
| SCHEMBL215759 | 0.84 | MAPT (0.58) | S1PR4ALDH1A1KMT2AAPOBEC3AHTT | |
| SCHEMBL6017266 | 0.84 | ALDH1A1 (0.59) | ALDH1A1KMT2AAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL6187801 | 0.84 | KMT2A (0.51) | ALDH1A1KMT2AAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL1406392 | 0.82 | ALDH1A1 (0.48) | ALDH1A1KMT2AAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL30963305 | 0.82 | ALDH1A1 (0.44) | ALDH1A1KMT2AAPOBEC3AHTTAPOBEC3G | |
| SCHEMBL3993993 | 0.82 | MAPT (0.56) | S1PR4ALDH1A1KMT2AAPOBEC3AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081461-B1 | Quinazoline compounds and pharmaceutical compositions containing them | ASTRAZENECA AB (SE) | 2006-07-25 | — | — | US | disclosed |
| EP-1218356-A1 | QUINAZOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021594-A1 | QUINAZOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |