Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29533974 | 1.00 | GLS (0.70) | GLSMAPTRXFP1HTTKCNH2 | |
| SCHEMBL30684934 | 0.90 | GLS (0.55) | GLSMAPTRXFP1HTTKCNH2 | |
| SCHEMBL6069704 | 0.90 | GLS (0.55) | GLSMAPTRXFP1HTTKCNH2 | |
| SCHEMBL14928249 | 0.82 | GLS (0.75) | GLSMAPTRXFP1HTTCYP19A1 | |
| SCHEMBL2933655 | 0.82 | GLS (0.75) | GLSMAPTCYP19A1CYP1A2PKM | |
| SCHEMBL6069456 | 0.82 | GLS (0.53) | GLSMAPTRXFP1HTTKCNH2 | |
| SCHEMBL5347812 | 0.82 | GLS (0.70) | GLSMAPTCYP19A1CYP1A2ALDH1A1 | |
| SCHEMBL3808355 | 0.82 | GLS (0.70) | GLSMAPTCYP19A1CYP1A2 | |
| SCHEMBL8671555 | 0.81 | GLS (0.68) | GLSMAPTCYP19A1CYP1A2 | |
| SCHEMBL31304164 | 0.80 | GLS (0.71) | GLSMAPTCYP19A1CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117263940-A | FGFR inhibitor, preparation method thereof, pharmaceutical composition and application | 中国药科大学 | 2023-12-22 | — | — | CN | disclosed |
| WO-2023178928-A1 | 2-AMINO-4-INDOLYL PYRIMIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND USES THEREOF | 中国药科大学 | 2023-09-28 | — | — | WO | disclosed |
| CN-114380806-B | 2-amino-4-indolyl pyrimidine compound and preparation method and application thereof | 中国药科大学 | 2022-06-10 | — | — | CN | disclosed |
| CN-114380806-A | 2-amino-4-indolyl pyrimidine compound and preparation method and application thereof | 中国药科大学 | 2022-04-22 | — | — | CN | disclosed |
| US-7071182-B2 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBOTT LABORATORIES (US) | 2006-07-04 | — | — | US | disclosed |
| US-20050277638-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBVIE INC. | 2005-12-15 | — | — | US | disclosed |
| US-20050137243-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBOTT LABORATORIES | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137243-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | GLS 1607/4885MAPT 228/4885RXFP1 90/4885 |
| US-20050277638-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | GLS 1607/4885MAPT 228/4885RXFP1 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.