Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL4601051 | 0.97 | ALDH1A1 (0.33) | ALDH1A1PTGS2HSD17B10 | |
| SCHEMBL2358712 | 0.84 | — | — | |
| SCHEMBL8986634 | 0.79 | — | — | |
| SCHEMBL253206 | 0.77 | — | — | |
| SCHEMBL277283 | 0.77 | ALDH1A1 (0.54) | ALDH1A1PTGS2HSD17B10 | |
| SCHEMBL3059548 | 0.76 | ALDH1A1 (0.30) | ALDH1A1PTGS2HSD17B10 | |
| Hydrazine SCHEMBL23925260 | 0.73 | — | — | |
| Ammonia Solution, Strong SCHEMBL7271342 | 0.73 | — | — | |
| Ammonia Solution, Strong SCHEMBL8813878 | 0.73 | ALDH1A1 (0.50) | ALDH1A1PTGS2HSD17B10 | |
| Methane SCHEMBL9323244 | 0.73 | ALDH1A1 (0.50) | ALDH1A1PTGS2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326853-B1 | THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | WARNER LAMBERT CO (US) | 2005-09-07 | — | — | EP | claimed |
| EP-1326853-A1 | NEW THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-07-16 | — | — | EP | claimed |
| US-20030045557-A1 | Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors | WARNER-LAMBERT COMPANY | 2003-03-06 | — | — | US | claimed |
| WO-2002028847-A1 | NEW THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-04-11 | — | — | WO | claimed |
| EP-1193261-A1 | New thiadiazoles and their use as phosphodiesterase-7 inhibitors | WARNER-LAMBERT COMPANY (US) | 2002-04-03 | — | — | EP | claimed |
| US-5300278-A | Binding antibodies | CIS BIO INTERNATIONAL (FR) | 1994-04-05 | — | — | US | claimed |
| EP-0403524-B1 | PREPARATION OF NITRURO COMPOUNDS USABLE AS RADIO-PHARMACEUTICAL PRODUCTS | CIS BIO INTERNATIONAL (FR) | 1993-02-10 | — | — | EP | claimed |
| EP-0403524-A1 | PREPARATION OF NITRURO COMPOUNDS USABLE AS RADIO-PHARMACEUTICAL PRODUCTS. | CIS BIO INT (FR) | 1990-12-27 | — | — | EP | claimed |
| WO-1989008657-A2 | PREPARATION OF NITRURO COMPOUNDS USABLE AS RADIO-PHARMACEUTICAL PRODUCTS | CIS BIO INTERNATONAL (FR) | 1989-09-21 | — | — | WO | claimed |
| CN-105130897-A | Nitrogen-sulfur substituent-containing naphthalimide compound, and preparation method and application thereof | UNIV DALIAN TECH | 2015-12-09 | — | — | CN | disclosed |
| US-7122565-B2 | Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors | WARNER-LAMBERT LLC (US) | 2006-10-17 | — | — | US | disclosed |
| EP-1326853-B1 | THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | WARNER LAMBERT CO (US) | 2005-09-07 | — | — | EP | disclosed |
| CN-1639141-A | Novel thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors | WARNER LAMBERT CO (US) | 2005-07-13 | — | — | CN | disclosed |
| EP-1326853-A1 | NEW THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-20030045557-A1 | Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors | WARNER-LAMBERT COMPANY | 2003-03-06 | — | — | US | disclosed |
| WO-2002028847-A1 | NEW THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-04-11 | — | — | WO | disclosed |
| EP-1193261-A1 | New thiadiazoles and their use as phosphodiesterase-7 inhibitors | WARNER-LAMBERT COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0445190-B1 | PHARMACEUTICAL PRODUCT HAVING, IN PARTICULAR, A CARDIAC TROPISM COMPRISING A NITRURO COMPLEX OF A TRANSITION METAL AND PROCESS FOR PREPARATION THEREOF | CIS BIO INTERNATIONAL (FR) | 1993-09-15 | — | — | EP | disclosed |
| WO-1990006137-A1 | PHARMACEUTICAL PRODUCT HAVING, IN PARTICULAR, A CARDIAC TROPISM COMPRISING A NITRURO COMPLEX OF A TRANSITION METAL AND PROCESS FOR PREPARATION THEREOF | CIS BIO INTERNATIONAL (FR) | 1990-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045557-A1 | Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors | PDE3A, PDE3B, PDE7A | ALDH1A1 471/4885PTGS2 882/4885HSD17B10 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.