Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.50 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071458 | 0.83 | MAPK10 (0.55) | ALDH1A1LMNAKMT2AMEN1KDM4E | |
| SCHEMBL6071141 | 0.82 | MAPK10 (0.54) | ALDH1A1LMNAKMT2AMEN1KDM4E | |
| SCHEMBL14863655 | 0.79 | HTT (0.60) | HTTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL14863654 | 0.79 | HTT (0.60) | HTTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6071166 | 0.79 | ALDH1A1 (0.55) | HTTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6070990 | 0.78 | MAPK10 (0.58) | ALDH1A1LMNAKMT2AMEN1KDM4E | |
| SCHEMBL6071308 | 0.78 | MAPK10 (0.63) | ALDH1A1LMNAKMT2AMEN1KDM4E | |
| SCHEMBL6071229 | 0.78 | MAPK10 (0.65) | ALDH1A1LMNAKMT2AMEN1KDM4E | |
| SCHEMBL6071331 | 0.77 | MAPK10 (0.60) | ALDH1A1LMNAKMT2AMEN1KDM4E | |
| SCHEMBL6071133 | 0.77 | MAPK10 (0.56) | ALDH1A1LMNAKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | HTT 1201/4885ALDH1A1 4446/4885LMNA 2808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.