Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071464 | 0.77 | AURKA (0.49) | HSD17B10KMT2AMEN1MAPK10RIPK1 | |
| Alcohol SCHEMBL28970833 | 0.68 | HSD17B10 (0.82) | HSD17B10KMT2AMEN1MAPK10RIPK1 | |
| SCHEMBL6071275 | 0.68 | AURKA (0.47) | HSD17B10KMT2AMEN1MAPK10RIPK1 | |
| Acetamide SCHEMBL27705466 | 0.67 | HSD17B10 (0.79) | HSD17B10KMT2AMEN1MAPK10RIPK1 | |
| SCHEMBL6071193 | 0.67 | KDM4E (0.50) | HSD17B10KMT2AMEN1MAPK10RIPK1 | |
| SCHEMBL6071395 | 0.66 | AURKA (0.50) | HSD17B10KMT2AMEN1MAPK10RIPK1 | |
| SCHEMBL29805597 | 0.66 | TSHR (0.56) | HSD17B10KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL2081436 | 0.66 | TSHR (0.56) | HSD17B10KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL2476853 | 0.66 | LMNA (0.43) | KMT2AKDM4EALDH1A1NPC1TSHR | |
| SCHEMBL2550010 | 0.66 | CDK2 (0.43) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | HSD17B10 4387/4885KMT2A 2104/4885MEN1 2523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.