Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.47 |
| ▸ | CCKBR | P32239 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070772 | 0.91 | MAPK10 (0.55) | MAPK10RIPK1ROCK2AURKANAMPT | |
| SCHEMBL6071573 | 0.89 | MAPK10 (0.56) | MAPK10RIPK1ROCK2AURKANAMPT | |
| SCHEMBL6070840 | 0.83 | ROCK2 (0.55) | MAPK10RIPK1ROCK2AURKANAMPT | |
| SCHEMBL6071548 | 0.83 | MAPK10 (0.49) | MAPK10RIPK1P2RY12MEN1KMT2A | |
| SCHEMBL6070648 | 0.82 | MAPK10 (0.55) | MAPK10RIPK1ROCK2AURKAMEN1 | |
| SCHEMBL6071636 | 0.79 | MAPK10 (0.55) | MAPK10RIPK1ROCK2AURKANAMPT | |
| SCHEMBL6071380 | 0.78 | ROCK2 (0.59) | MAPK10RIPK1ROCK2AURKANAMPT | |
| SCHEMBL6071450 | 0.78 | MAPK10 (0.52) | MAPK10RIPK1AURKAMEN1KMT2A | |
| SCHEMBL6070716 | 0.78 | MAPK10 (0.61) | MAPK10RIPK1AURKAP2RY12MEN1 | |
| SCHEMBL6070589 | 0.76 | MAPK10 (0.59) | MAPK10RIPK1AURKAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | claimed |
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | MAPK10 387/4885RIPK1 131/4885ROCK2 698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.