Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 1/20 | 0.68 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.64 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.60 |
| ▸ | CD38 | P28907 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 6/20 | 0.55 |
| ▸ | ACP1 | P24666 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.50 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4961504 | 0.87 | CD38 (0.61) | FADS1PTK6EGFRTGFBR1CD38 | |
| SCHEMBL4740968 | 0.85 | CD38 (0.65) | FADS1PTK6EGFRTGFBR1CD38 | |
| SCHEMBL30307426 | 0.83 | FADS1 (0.60) | FADS1EGFRTGFBR1KDRERBB2 | |
| SCHEMBL23117519 | 0.83 | CD38 (0.62) | FADS1PTK6EGFRCD38RIPK2 | |
| SCHEMBL6071379 | 0.82 | PTK6 (0.59) | FADS1PTK6EGFRTGFBR1CD38 | |
| SCHEMBL30307407 | 0.82 | FADS1 (0.70) | FADS1EGFRKDRERBB2HTT | |
| SCHEMBL4787800 | 0.82 | CD38 (0.64) | FADS1PTK6EGFRCD38KDR | |
| SCHEMBL4740569 | 0.81 | FADS1 (1.00) | FADS1PTK6EGFRTGFBR1KDR | |
| SCHEMBL6071332 | 0.81 | ACP1 (0.63) | PTK6EGFRACP1ABCG2 | |
| SCHEMBL15673390 | 0.79 | ERBB2 (0.66) | FADS1EGFRTGFBR1KDRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | FADS1 3286/4885PTK6 180/4885EGFR 4122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.