Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30597565 | 0.74 | ALDH1A1 (0.61) | ALDH1A1LMNASMN1; SMN2CYP3A4MAPT | |
| SCHEMBL27597666 | 0.73 | ALDH1A1 (0.56) | ALDH1A1LMNASMN1; SMN2CYP3A4MAPT | |
| SCHEMBL31414427 | 0.72 | ALDH1A1 (0.58) | ALDH1A1LMNASMN1; SMN2CYP3A4MAPT | |
| SCHEMBL11868351 | 0.72 | ALDH1A1 (0.59) | ALDH1A1LMNASMN1; SMN2CYP3A4MAPT | |
| SCHEMBL377142 | 0.72 | ALDH1A1 (0.58) | ALDH1A1LMNASMN1; SMN2CYP3A4MAPT | |
| SCHEMBL27830076 | 0.71 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2CYP3A4MAPT | |
| SCHEMBL4961753 | 0.71 | PARP1 (0.61) | ALDH1A1CYP3A4PARP1 | |
| SCHEMBL11720245 | 0.71 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2CYP3A4MAPT | |
| SCHEMBL29923361 | 0.71 | PARP1 (0.61) | ALDH1A1CYP3A4PARP1 | |
| SCHEMBL6559835 | 0.71 | ALDH1A1 (0.57) | ALDH1A1LMNASMN1; SMN2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | ALDH1A1 3975/4885LMNA 2364/4885SMN1; SMN2 4362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.