Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072091 | 0.81 | ADRA2A (0.45) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6072067 | 0.80 | KDM4E (0.51) | ADRA2AADRA1AKDM4EALDH1A1GLA | |
| SCHEMBL6071634 | 0.79 | KDM4E (0.42) | ADRA2AADRA1AKDM4EALDH1A1GLA | |
| SCHEMBL6071875 | 0.74 | KDM4E (0.42) | ADRA2AADRA1AKDM4EALDH1A1GLA | |
| SCHEMBL6071415 | 0.73 | KDM4E (0.41) | ADRA2AADRA1AKDM4EALDH1A1GLA | |
| SCHEMBL6072127 | 0.71 | CYP1A2 (0.45) | ADRA2AADRA1AKDM4EALDH1A1GLA | |
| SCHEMBL6071684 | 0.71 | KDM4E (0.41) | ADRA2AADRA1AKDM4EALDH1A1CYP2D6 | |
| SCHEMBL6252164 | 0.69 | KDM4E (0.60) | ADRA2AADRA1AKDM4EALDH1A1CYP2D6 | |
| SCHEMBL9791332 | 0.68 | ADORA1 (0.62) | ADRA2AADRA1AKDM4EALDH1A1GLA | |
| SCHEMBL18459144 | 0.67 | KDM4E (0.56) | ADRA2AADRA1AKDM4EALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | ADRA2A 3607/4885ADRA1A 2901/4885ADRA2B 3599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.