SCHEMBL6072226

SCHEMBL6072226

CCOc1cc2c(c3c1OC(C)(C)C3)C(c1ccc(C=C(C)C(=O)O)cc1)=NC(C)(C)C2

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 3/20 0.32
KMT2A Q03164 3/20 0.30
POLB P06746 2/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6072222 1.00 FFAR4 (0.32) FFAR4KMT2APOLBMEN1
SCHEMBL6071970 0.87 KDM4E (0.40) FFAR4KMT2APOLBMEN1
SCHEMBL6071980 0.87 KDM4E (0.40) FFAR4KMT2APOLBMEN1
Hydrochloric Acid SCHEMBL5784450 0.85 SSTR5 (0.39)
SCHEMBL6071798 0.85 FFAR4 (0.33) FFAR4KMT2A
SCHEMBL6071791 0.85 FFAR4 (0.33) FFAR4KMT2A
SCHEMBL6071794 0.85 FFAR4 (0.33) FFAR4KMT2A
SCHEMBL6071737 0.84 SSTR5 (0.41) FFAR4
SCHEMBL6071698 0.84 SSTR5 (0.33) FFAR4
SCHEMBL5783874 0.84 SSTR5 (0.34) KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060106048-A1 Furoisoquinoline derivative and use thereof PASCALI, PETROS P. (CY) 2006-05-18 US disclosed
EP-1541576-A1 FUROISOQUINOLINE DERIVATIVE AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2005-06-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060106048-A1 Furoisoquinoline derivative and use thereof PDE3B, PDE2A, PDE3A FFAR4 272/4885KMT2A 878/4885POLB 1887/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.