Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 8/20 | 0.39 |
| ▸ | NPR3 | P17342 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073783 | 1.00 | CCND3 (0.41) | CCND3CDK4CCND1CCND2IGF1R | |
| SCHEMBL6073824 | 0.92 | CCND3 (0.41) | CCND3CDK4CCND1CCND2IGF1R | |
| SCHEMBL6073827 | 0.92 | CCND3 (0.41) | CCND3CDK4CCND1CCND2IGF1R | |
| SCHEMBL6074187 | 0.89 | FGFR1 (0.41) | CCND3CDK4CCND1CCND2IGF1R | |
| SCHEMBL6074180 | 0.89 | FGFR1 (0.41) | CCND3CDK4CCND1CCND2IGF1R | |
| SCHEMBL6073956 | 0.89 | CCND3 (0.53) | CCND3CDK4CCND1CCND2IGF1R | |
| SCHEMBL6074137 | 0.87 | AURKB (0.41) | CCND3CDK4CCND1CCND2SYK | |
| SCHEMBL6074141 | 0.87 | AURKB (0.41) | CCND3CDK4CCND1CCND2SYK | |
| SCHEMBL6073608 | 0.85 | CDK4 (0.48) | CCND3CDK4CCND1CCND2SYK | |
| SCHEMBL6073614 | 0.85 | CDK4 (0.48) | CCND3CDK4CCND1CCND2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053070-B2 | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-05-30 | — | — | US | disclosed |
| US-20030073668-A1 | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors | BOOTH RICHARD JOHN (US) | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073668-A1 | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors | CDK9, CDK19, CDK3 | CCND3 98/4885CDK4 19/4885CCND1 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.