Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | CASP1 | P29466 | 5/20 | 0.40 |
| ▸ | CASP7 | P55210 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | PREP | P48147 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073947 | 0.80 | ACE (0.35) | ALDH1A1CYP1A2CASP1CASP7HSD17B10 | |
| SCHEMBL31486537 | 0.79 | RPS6KB1 (0.39) | ACEPREP | |
| SCHEMBL31486254 | 0.77 | NPFFR1 (0.39) | ALDH1A1PREPGAA | |
| SCHEMBL31486250 | 0.75 | ACE (0.39) | CYP1A2CASP1CASP7HSD17B10CLK4 | |
| SCHEMBL6073397 | 0.73 | F2 (0.35) | ALDH1A1CYP1A2CASP1CASP7HSD17B10 | |
| SCHEMBL6074128 | 0.65 | F7 (0.41) | ALDH1A1CYP1A2CASP1CASP7HSD17B10 | |
| SCHEMBL6073813 | 0.65 | F7 (0.45) | ALDH1A1CYP1A2CASP1CASP7HSD17B10 | |
| SCHEMBL18893459 | 0.64 | ACE (0.36) | ALDH1A1ACE | |
| SCHEMBL31486218 | 0.64 | ACE (0.36) | ALDH1A1ACE | |
| SCHEMBL6073814 | 0.64 | F7 (0.45) | HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037911-B2 | Amino-bicyclic pyrazinones and pyridinones as coagulation serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| US-20050038030-A1 | Amino-bicyclic pyrazinones and pyridinones as coagulation serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038030-A1 | Amino-bicyclic pyrazinones and pyridinones as coagulation serine protease inhibitors | TFPI, F5, F2 | ALDH1A1 2757/4885CYP1A2 651/4885CASP1 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.