Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 14/20 | 0.80 |
| ▸ | CCR3 | P51677 | 14/20 | 0.80 |
| ▸ | CCR1 | P32246 | 4/20 | 0.80 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD4 | P21917 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212138 | 0.95 | HRH1 (0.72) | HRH1CCR3CCR1ABCB11KCNH2 | |
| Hydrochloric Acid SCHEMBL7494378 | 0.94 | HRH1 (0.72) | HRH1CCR3CCR1ABCB11KCNH2 | |
| Hydrochloric Acid SCHEMBL6215275 | 0.94 | HRH1 (0.71) | HRH1CCR3CCR1ABCB11KCNH2 | |
| SCHEMBL6074823 | 0.91 | HRH1 (0.78) | HRH1CCR3CCR1KCNH2DRD2 | |
| SCHEMBL6075260 | 0.91 | HRH1 (0.77) | HRH1CCR3CCR1KCNH2DRD2 | |
| SCHEMBL6214541 | 0.91 | HRH1 (0.67) | HRH1CCR3CCR1KCNH2DRD2 | |
| SCHEMBL6214546 | 0.91 | HRH1 (0.67) | HRH1CCR3CCR1KCNH2DRD2 | |
| SCHEMBL6216373 | 0.91 | HRH1 (0.67) | HRH1CCR3CCR1KCNH2DRD2 | |
| SCHEMBL6210978 | 0.91 | HRH1 (0.67) | HRH1CCR3CCR1KCNH2DRD2 | |
| SCHEMBL6210512 | 0.90 | HRH1 (0.66) | HRH1CCR3CCR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263724-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | claimed |
| US-20030149047-A1 | Novel compounds | ASTRAZENCA AB (SE) | 2003-08-07 | — | — | US | claimed |
| EP-1263724-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | claimed |
| WO-2001062728-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | claimed |
| US-7005439-B2 | Compounds | ASTRAZENECA AB (SE) | 2006-02-28 | — | — | US | disclosed |
| US-6951874-B2 | Compounds | ASTRAZENECA AB (SE) | 2005-10-04 | — | — | US | disclosed |
| US-6943188-B2 | Hydroxyalkyl compounds | ASTRAZENECA AB (SE) | 2005-09-13 | — | — | US | disclosed |
| US-6927222-B2 | 1,3,4,5-tetrahydro-pyrido(4,3-b)indole-2-yl derivative useful for treating rheumatoid arthritis, chronic obstructive pulmonary disease, asthma and multple sclerosis | ASTRAZENECA AB (SE) | 2005-08-09 | — | — | US | disclosed |
| EP-1263724-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |
| EP-1263725-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-10-20 | — | — | EP | disclosed |
| EP-1299356-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-11 | — | — | EP | disclosed |
| CN-1458281-A | Coronary virus RNA interference preparation for severe acute respiratory syndrome pathogen | HUANQIU ZHONGJIA BIOLOG SCIENC (CN) | 2003-11-26 | — | — | CN | disclosed |
| EP-1299356-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| EP-1263760-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| EP-1263724-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| EP-1263725-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001098272-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-12-27 | — | — | WO | disclosed |
| WO-2001062757-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |
| WO-2001062728-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |
| WO-2001062729-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149047-A1 | Novel compounds | RPS4Y1, RPS4X, RPS6 | HRH1 545/4885CCR3 1515/4885CCR1 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.