Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4157549 | 0.89 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP19A1CYP3A4TRIM24 | |
| SCHEMBL6074004 | 0.88 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP19A1CYP3A4TRIM24 | |
| SCHEMBL6074045 | 0.81 | CYP11B1 (0.46) | CYP11B1CYP11B2CYP19A1CYP3A4TRIM24 | |
| SCHEMBL12057333 | 0.78 | CYP11B1 (0.52) | CYP11B1CYP11B2CYP19A1CYP3A4TRIM24 | |
| SCHEMBL6074490 | 0.76 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP19A1CYP3A4TRIM24 | |
| SCHEMBL4156212 | 0.73 | CYP11B1 (0.48) | CYP11B1CYP11B2CYP19A1CYP3A4TRIM24 | |
| SCHEMBL6073535 | 0.73 | CYP11B1 (0.46) | CYP11B1CYP11B2CYP19A1CYP3A4TRIM24 | |
| SCHEMBL16431883 | 0.73 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1CYP3A4TRIM24 | |
| SCHEMBL6073506 | 0.72 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP19A1CYP3A4TRIM24 | |
| SCHEMBL23011989 | 0.71 | MAP3K5 (0.45) | CYP11B1CYP11B2CYP19A1CYP3A4TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119207-B2 | Benzoamide piperidine containing compounds and related compounds | PFIZER INC (US) | 2006-10-10 | — | — | US | disclosed |
| US-20030087925-A1 | Benzoamide piperidine containing compounds and related compounds | PFIZER INC. | 2003-05-08 | — | — | US | disclosed |
| EP-1272484-A2 | BENZOAMIDE PIPERIDINE COMPOUNDS AS SUBSTANCE P ANTAGONISTS | Pfizer Products Inc. (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001077100-A2 | BENZOAMIDE PIPERIDINE COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2001-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087925-A1 | Benzoamide piperidine containing compounds and related compounds | TACR1, VIPR1, VIPR2 | CYP11B1 2904/4885CYP11B2 3109/4885CYP19A1 918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.