Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6074541 | 0.88 | PDE5A (0.68) | PDE5A | |
| SCHEMBL6409670 | 0.86 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6407260 | 0.86 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6290660 | 0.86 | PDE5A (1.00) | PDE5A | |
| SCHEMBL7099126 | 0.84 | PDE5A (0.54) | PDE5A | |
| SCHEMBL6076067 | 0.83 | PDE5A (0.64) | PDE5A | |
| SCHEMBL6406398 | 0.83 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6407101 | 0.82 | PDE5A (0.77) | PDE5A | |
| SCHEMBL2727409 | 0.81 | PDE5A (0.76) | PDE5A | |
| SCHEMBL4929135 | 0.80 | PDE5A (0.78) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360185-B1 | CARBOLINE DERIVATIVES | LILLY ICOS LLC (US) | 2005-08-24 | — | — | EP | claimed |
| US-20040122035-A1 | Chemical compounds | LILLY ICOS LLC | 2004-06-24 | — | — | US | claimed |
| US-7022856-B2 | Carboline derivatives | LILLY ICOS LLC. (US) | 2006-04-04 | — | — | US | disclosed |
| EP-1360185-B1 | CARBOLINE DERIVATIVES | LILLY ICOS LLC (US) | 2005-08-24 | — | — | EP | disclosed |
| US-20040122035-A1 | Chemical compounds | LILLY ICOS LLC | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122035-A1 | Chemical compounds | ABCG2, CYP11B1, CYP2F1 | PDE5A 2238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.