Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.64 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | PDE6A | P16499 | 1/20 | 0.47 |
| ▸ | PDE6G | P18545 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | PDE6B | P35913 | 1/20 | 0.47 |
| ▸ | PDE6C | P51160 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.47 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.47 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6074541 | 0.86 | PDE5A (0.68) | PDE5AABCB1ABCG2 | |
| SCHEMBL6074804 | 0.83 | PDE5A (0.75) | PDE5A | |
| SCHEMBL5880569 | 0.80 | PDE5A (0.43) | PDE5AACHEMAPK1 | |
| SCHEMBL6407260 | 0.78 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6290660 | 0.78 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6409670 | 0.78 | PDE5A (1.00) | PDE5A | |
| SCHEMBL2727409 | 0.76 | PDE5A (0.76) | PDE5A | |
| SCHEMBL6406398 | 0.75 | PDE5A (1.00) | PDE5A | |
| SCHEMBL30539389 | 0.74 | PDE5A (0.62) | PDE5APDE6DNR1I2PDE6APDE6G | |
| SCHEMBL6290663 | 0.74 | PDE5A (0.71) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360185-B1 | CARBOLINE DERIVATIVES | LILLY ICOS LLC (US) | 2005-08-24 | — | — | EP | claimed |
| US-20040122035-A1 | Chemical compounds | LILLY ICOS LLC | 2004-06-24 | — | — | US | claimed |
| US-7022856-B2 | Carboline derivatives | LILLY ICOS LLC. (US) | 2006-04-04 | — | — | US | disclosed |
| EP-1360185-B1 | CARBOLINE DERIVATIVES | LILLY ICOS LLC (US) | 2005-08-24 | — | — | EP | disclosed |
| US-20040122035-A1 | Chemical compounds | LILLY ICOS LLC | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122035-A1 | Chemical compounds | ABCG2, CYP11B1, CYP2F1 | PDE5A 2238/4885PDE6D 1560/4885NR1I2 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.