Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | PIEZO1 | Q92508 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30767271 | 0.85 | IDO1 (0.50) | RAB9ANPC1MAPTPKMMEN1 | |
| SCHEMBL3948151 | 0.85 | IDO1 (0.50) | RAB9ANPC1MAPTPKMMEN1 | |
| SCHEMBL27604626 | 0.84 | RAB9A (0.42) | RAB9ANPC1MAPTPKMALDH1A1 | |
| SCHEMBL29712861 | 0.82 | NPC1 (0.43) | RAB9ANPC1MAPTPKMALDH1A1 | |
| SCHEMBL28632051 | 0.82 | NPC1 (0.43) | RAB9ANPC1MAPTPKMALDH1A1 | |
| SCHEMBL5243501 | 0.82 | NPC1 (0.45) | RAB9ANPC1MAPTPKMALDH1A1 | |
| SCHEMBL5406690 | 0.82 | NOTUM (0.41) | RAB9ANPC1PKMSMN1; SMN2KDM4E | |
| SCHEMBL17295714 | 0.82 | RAB9A (0.44) | RAB9ANPC1MAPTPKMALDH1A1 | |
| SCHEMBL16574222 | 0.79 | IDO1 (0.53) | RAB9ANPC1PKMMEN1KMT2A | |
| SCHEMBL23032500 | 0.78 | ADORA2A (0.44) | RAB9ANPC1ALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6995161-B2 | Substituted arylpyrazines | NEUROGEN CORPORATION (US) | 2006-02-07 | — | — | US | disclosed |
| EP-0204172-B1 | PHENYLPYRAZINE DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE | SUNTORY LIMITED (JP) | 1990-09-19 | — | — | EP | disclosed |
| US-4755514-A | Phenylpyrazine derivatives and thrombolytic agent | SUNTORY LIMITED (JP) | 1988-07-05 | — | — | US | disclosed |
| EP-0204172-A2 | Phenylpyrazine derivatives, processes for preparing them, pharmaceutical composition and use | SUNTORY LIMITED (JP) | 1986-12-10 | — | — | EP | disclosed |