Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075144 | 0.95 | ACP1 (0.42) | ADORA1MAPTALDH1A1HPGDHTT | |
| SCHEMBL6075371 | 0.91 | IGF1R (0.42) | ADORA1MAPTALDH1A1HPGDHTT | |
| SCHEMBL6076160 | 0.91 | ACP1 (0.45) | ADORA1MAPTALDH1A1HPGDHTT | |
| SCHEMBL6076928 | 0.90 | PDE5A (0.46) | ADORA1MAPTALDH1A1HPGDHTT | |
| SCHEMBL6075878 | 0.89 | ADORA1 (0.47) | ADORA1MAPTTP53ALDH1A1HPGD | |
| SCHEMBL6075874 | 0.89 | ADORA1 (0.47) | ADORA1MAPTTP53ALDH1A1HPGD | |
| SCHEMBL5732654 | 0.89 | ACP1 (0.45) | ADORA1MAPTALDH1A1HPGDHTT | |
| SCHEMBL5734979 | 0.88 | PDE5A (0.46) | ADORA1GBA1ACP1IGF1RPDE4B | |
| SCHEMBL5732459 | 0.87 | ADORA1 (0.47) | ADORA1MAPTALDH1A1HPGDHTT | |
| SCHEMBL5732457 | 0.87 | ADORA1 (0.47) | ADORA1MAPTALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045526-B2 | Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-05-16 | — | — | US | claimed |