Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075874 | 1.00 | ADORA1 (0.47) | ADORA1ADORA2AADORA3ADORA2BSGK1 | |
| SCHEMBL5732459 | 0.98 | ADORA1 (0.47) | ADORA1ADORA2AADORA3ADORA2BSGK1 | |
| SCHEMBL5732457 | 0.98 | ADORA1 (0.47) | ADORA1ADORA2AADORA3ADORA2BSGK1 | |
| SCHEMBL6075144 | 0.94 | ACP1 (0.42) | ADORA1ADORA2AADORA3PDE4BALDH1A1 | |
| SCHEMBL6075371 | 0.90 | IGF1R (0.42) | ADORA1ADORA2AADORA3PDE4BALDH1A1 | |
| SCHEMBL6076160 | 0.90 | ACP1 (0.45) | ADORA1ADORA2AADORA3PDE4BALDH1A1 | |
| SCHEMBL6075770 | 0.89 | ADORA1 (0.45) | ADORA1PDE4BALDH1A1HPGDMAPT | |
| SCHEMBL6076928 | 0.89 | PDE5A (0.46) | ADORA1ADORA2AADORA3PDE4BALDH1A1 | |
| SCHEMBL6076015 | 0.88 | ADORA2A (0.45) | ADORA1ADORA2AADORA3ADORA2BSGK1 | |
| SCHEMBL6076012 | 0.88 | ADORA2A (0.45) | ADORA1ADORA2AADORA3ADORA2BSGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045526-B2 | Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-05-16 | — | — | US | claimed |