Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CTSK | P43235 | 8/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29890909 | 0.88 | CA1 (0.51) | CA1CA2CA7CTSKCA4 | |
| SCHEMBL6405983 | 0.80 | CA1 (0.46) | CA1CA2CA7CTSKCA4 | |
| SCHEMBL29681372 | 0.79 | CA1 (0.56) | CA1CA2CA7CTSKCA4 | |
| SCHEMBL6661458 | 0.79 | CA1 (0.56) | CA1CA2CA7CTSKCA4 | |
| SCHEMBL2519000 | 0.79 | CA1 (0.56) | CA1CA2CA7CTSKCA4 | |
| SCHEMBL24554689 | 0.79 | CA1 (0.56) | CA1CA2CA7CTSKCA4 | |
| SCHEMBL4549626 | 0.77 | CA1 (0.54) | CA1CA2CA7CTSKCA4 | |
| SCHEMBL24136470 | 0.77 | CA1 (0.58) | CA1CA2CA7CTSKCYP2D6 | |
| SCHEMBL6400709 | 0.77 | SYK (0.40) | CA1CA2CA7CTSKCA9 | |
| SCHEMBL4549628 | 0.76 | CA1 (0.53) | CA1CA2CA7CTSKCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7038055-B2 | Sulfone derivatives and their use in the treatment of autoimmune diseases and allergies | SMITHKLINEBEECHAM PLC (GB) | 2006-05-02 | — | — | US | disclosed |
| EP-1448529-B1 | SULFONE DERIVATIVES SUITABLE FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND ALLERGIES | SMITHKLINE BEECHAM PLC (GB) | 2005-07-13 | — | — | EP | disclosed |
| US-20050070572-A1 | Sulfone derivatives and their use in the treatment of autoimmune diseases and allergies | SMITHKLINE BEECHAM PLC (GB) | 2005-03-31 | — | — | US | disclosed |
| EP-1448529-A1 | SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AND ALLERGIES | SMITHKLINE BEECHAM PLC (GB) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045922-A1 | SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AND ALLERGIES | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070572-A1 | Sulfone derivatives and their use in the treatment of autoimmune diseases and allergies | CD2, SSB, CD22 | CA1 785/4885CA2 645/4885CA7 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.