Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6663806 | 0.86 | CYP1A2 (0.37) | CYP1A2ALPLHIF1AEPAS1PDE10A | |
| SCHEMBL6078652 | 0.85 | KMT2A (0.40) | CYP1A2HIF1AEPAS1PDE10AKMT2A | |
| SCHEMBL6078647 | 0.85 | KMT2A (0.40) | CYP1A2HIF1AEPAS1PDE10AKMT2A | |
| SCHEMBL6400334 | 0.83 | CYP1A2 (0.38) | CYP1A2ALPLHIF1AEPAS1PDE10A | |
| SCHEMBL6400327 | 0.83 | CYP1A2 (0.38) | CYP1A2ALPLHIF1AEPAS1PDE10A | |
| SCHEMBL6078177 | 0.83 | KDM4E (0.40) | CYP1A2HIF1AEPAS1KMT2AKDM4E | |
| SCHEMBL6079552 | 0.83 | KDM4E (0.40) | CYP1A2HIF1AEPAS1KMT2AKDM4E | |
| SCHEMBL6607764 | 0.82 | MMP2 (0.38) | CYP1A2ALPLHIF1AEPAS1PDE10A | |
| SCHEMBL6607771 | 0.82 | MMP2 (0.38) | CYP1A2ALPLHIF1AEPAS1PDE10A | |
| SCHEMBL6609601 | 0.81 | CYP1A2 (0.39) | CYP1A2ALPLHIF1AEPAS1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7038055-B2 | Sulfone derivatives and their use in the treatment of autoimmune diseases and allergies | SMITHKLINEBEECHAM PLC (GB) | 2006-05-02 | — | — | US | disclosed |
| EP-1448529-B1 | SULFONE DERIVATIVES SUITABLE FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND ALLERGIES | SMITHKLINE BEECHAM PLC (GB) | 2005-07-13 | — | — | EP | disclosed |
| US-20050070572-A1 | Sulfone derivatives and their use in the treatment of autoimmune diseases and allergies | SMITHKLINE BEECHAM PLC (GB) | 2005-03-31 | — | — | US | disclosed |
| EP-1448529-A1 | SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AND ALLERGIES | SMITHKLINE BEECHAM PLC (GB) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045922-A1 | SULFONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AND ALLERGIES | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070572-A1 | Sulfone derivatives and their use in the treatment of autoimmune diseases and allergies | CD2, SSB, CD22 | CYP1A2 518/4885ALPL 1845/4885HIF1A 2438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.