Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.48 |
| ▸ | F10 | P00742 | 4/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.48 |
| ▸ | F12 | P00748 | 2/20 | 0.47 |
| ▸ | F7 | P08709 | 2/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079110 | 0.97 | F2 (0.51) | F2PRSS1F10PRSS2PRSS3 | |
| SCHEMBL6078374 | 0.89 | F2 (0.60) | F2PRSS1F10PRSS2PRSS3 | |
| SCHEMBL6077392 | 0.83 | F2 (0.61) | F2PRSS1F10PRSS2PRSS3 | |
| SCHEMBL6079038 | 0.80 | F11 (0.40) | F2 | |
| SCHEMBL6077633 | 0.78 | F2 (0.59) | F2F12 | |
| SCHEMBL21067851 | 0.77 | F2 (0.67) | F2PRSS1F10PRSS2PRSS3 | |
| SCHEMBL21067854 | 0.77 | F2 (0.67) | F2PRSS1F10PRSS2PRSS3 | |
| SCHEMBL6079191 | 0.77 | F2 (0.60) | F2PRSS1F10PRSS2PRSS3 | |
| SCHEMBL6079772 | 0.76 | F2 (0.50) | F2PRSS1F10PRSS3F12 | |
| SCHEMBL6079120 | 0.76 | F11 (0.42) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | F2 1/4885PRSS1 106/4885F10 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.