Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formaldehyde SCHEMBL6083170 | 0.97 | BRD4 (0.36) | BRD4BRDTTSHRCHRNB2CHRNA4 | |
| SCHEMBL10460267 | 0.83 | GAA (0.50) | BRD4TSHRL3MBTL1GAAALDH1A1 | |
| SCHEMBL19420091 | 0.81 | MAPT (0.48) | EPHX1L3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19420078 | 0.81 | MAPT (0.48) | EPHX1L3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5765921 | 0.81 | MAPT (0.48) | EPHX1L3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| Ethylene SCHEMBL10458550 | 0.80 | GAA (0.47) | BRD4TSHRL3MBTL1GAAALDH1A1 | |
| SCHEMBL3621172 | 0.79 | BRD4 (0.38) | BRD4BRDTTSHRCHRNB2CHRNA4 | |
| SCHEMBL3621568 | 0.73 | GAA (0.43) | TSHRL3MBTL1GAAMAPTALDH1A1 | |
| SCHEMBL771850 | 0.72 | GAA (0.53) | BRD4BRDTTSHRCHRNB2CHRNA4 | |
| SCHEMBL17787817 | 0.72 | GAA (0.34) | BRD4BRDTTSHREPHX1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014083150-A1 | PREPARATION OF 3-AMINO-PIPERIDINE COMPOUNDS VIA NITRO-TETRAHYDROPYRIDINE PRECURSORS | LEK PHARMACEUTICALS D.D. (SI) | 2014-06-05 | — | — | WO | disclosed |
| CN-103755624-A | Synthetic method of piperidine derivative | LANZHOU BOC CHEMICAL CO LTD | 2014-04-30 | — | — | CN | disclosed |
| US-7084277-B2 | Reacting 1-alkoxycarbonyl-3-oxo piperidine compound with an amine; reducing with reducing agent | PFIZER INC. (US) | 2006-08-01 | — | — | US | disclosed |
| EP-1572649-A2 | 3-AMINO-PIPERIDINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | Pfizer Products Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004046112-A2 | 3-AMINO-PIPERIDINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | PFIZER PRODUCTS INC. (US) | 2004-06-03 | — | — | WO | disclosed |
| US-20040102627-A1 | 3-Amino-piperadine derivatives and methods of manufacture | PFIZER INC. | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102627-A1 | 3-Amino-piperadine derivatives and methods of manufacture | PRMT5, SRM, CYP1B1 | BRD4 568/4885BRDT 3936/4885TSHR 3290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.