SRM — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL30249742	1.00	5/20
SCHEMBL11037776	0.69	5/20
SCHEMBL11040771	0.69	5/20
SCHEMBL11040828	0.69	5/20
SCHEMBL11044260	0.69	5/20
Hydrochloric Acid (SCHEMBL11043510)	0.68	5/20
SCHEMBL11042510	0.68	5/20
SCHEMBL11040743	0.67	5/20
SCHEMBL11041134	0.64	5/20
SCHEMBL11165247	0.61	5/20
SCHEMBL5055541	0.76	4/20
SCHEMBL1770054	0.69	4/20
SCHEMBL5007882	0.67	4/20
SCHEMBL6907682	0.64	4/20
SCHEMBL10665708	0.64	4/20
SCHEMBL8388991	0.64	4/20
SCHEMBL11043633	0.62	4/20
SCHEMBL8385440	0.62	4/20
SCHEMBL3400828	0.60	4/20
SCHEMBL29941424	0.60	4/20

Clinical trials — most relevant to SRM by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arsenic	PHASE4	COMPLETED
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial	PHASE2	COMPLETED
Polyamine Treatment in Elderly Patients With Coronary Artery Disease	PHASE2	ACTIVE_NOT_RECRUITING
Polyamine-enriched Diet in Healthy Older Adults With Subjective Cognitive Decline	PHASE2	COMPLETED
STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH	PHASE2	COMPLETED
The STRETCH Study: Distensibility on Endothelial-Dependent Vasoreactivity in Subjects With Systolic Hypertension	PHASE2	COMPLETED
An Exploratory Clinical Study on Autophagy and Multi-level Molecular Profiling During Spermidine Supplementation	nan	UNKNOWN
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
Urinary Excretion of Acetylamantadine by Normal Healthy Volunteers	nan	COMPLETED
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels	nan	COMPLETED
Dietary Effects of Sulfur Amino Acids	nan	COMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Multi-omics Study in Citrin Deficiency	nan	ACTIVE_NOT_RECRUITING
Autophagy and Venous Endothelial Function	nan	UNKNOWN
Characterization of the Pharmacokinetics of Oral Selenium Compounds in Humans Before and Following Supplementation	nan	COMPLETED
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
External Nitric Oxide Measurement Through SNO Degradation	nan	ENROLLING_BY_INVITATION
Arginine Metabolism in Youth With Type 2 Diabetes	nan	RECRUITING
Harmonized Micronutrient Project	nan	COMPLETED
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial	nan	COMPLETED
Valproic Acid-associated Hypoalbuminemia in Medically Fragile Patients	nan	COMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Treating Oxidative Stress and the Metabolic Pathology of Autism	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SRM binder may also engage these)

Protein	Name	Similarity
Q64674	—	1.000	Q64674 →
Q9ZTR1	—	0.984	Q9ZTR1 →
O48661	—	0.981	O48661 →
Q9ZS45	—	0.980	Q9ZS45 →
Q9SMB1	—	0.979	Q9SMB1 →
Q9ZTR0	—	0.977	Q9ZTR0 →
Q09741	—	0.976	Q09741 →
O48659	—	0.975	O48659 →
Q8R123	—	0.974	Q8R123 →
O82147	—	0.973	O82147 →
Q9ZUB3	—	0.973	Q9ZUB3 →
O48658	—	0.973	O48658 →
Q9S7X6	—	0.972	Q9S7X6 →
Q96557	—	0.972	Q96557 →
Q96556	—	0.972	Q96556 →
Q9Y8H7	—	0.971	Q9Y8H7 →
Q8EXA3	—	0.971	Q8EXA3 →
Q884N3	—	0.971	Q884N3 →
Q94BN2	—	0.971	Q94BN2 →
Q9XY92	—	0.970	Q9XY92 →
O48660	—	0.970	O48660 →
P97355	—	0.969	P97355 →
SMS	Spermine synthase	0.969	landscape →
B2SHF6	—	0.969	B2SHF6 →
Q5EAD2	—	0.968	Q5EAD2 →
Q9NZC7	—	0.968	Q9NZC7 →
Q8TB37	—	0.968	Q8TB37 →
Q2P928	—	0.968	Q2P928 →
Q6NTR1	—	0.968	Q6NTR1 →
B3DLB3	—	0.968	B3DLB3 →