Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 3/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.54 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079023 | 1.00 | ALDH1A1 (0.58) | ALDH1A1LMNAGAASMN1; SMN2MAPK1 | |
| SCHEMBL6078369 | 1.00 | ALDH1A1 (0.58) | ALDH1A1LMNAGAASMN1; SMN2MAPK1 | |
| SCHEMBL6382811 | 1.00 | ALDH1A1 (0.58) | ALDH1A1LMNAGAASMN1; SMN2MAPK1 | |
| SCHEMBL372609 | 0.99 | ALDH1A1 (0.56) | ALDH1A1LMNAGAASMN1; SMN2MAPK1 | |
| SCHEMBL372675 | 0.97 | ALDH1A1 (0.54) | ALDH1A1LMNAGAASMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL492003 | 0.96 | ALDH1A1 (0.53) | ALDH1A1LMNAGAASMN1; SMN2MAPK1 | |
| SCHEMBL6078980 | 0.87 | MAPK1 (0.54) | ALDH1A1LMNAGAASMN1; SMN2MAPK1 | |
| SCHEMBL6078711 | 0.87 | MAPK1 (0.54) | ALDH1A1LMNAGAASMN1; SMN2MAPK1 | |
| SCHEMBL2202304 | 0.87 | MAPK1 (0.57) | ALDH1A1LMNAGAASMN1; SMN2MAPK1 | |
| SCHEMBL6078229 | 0.87 | MAPK1 (0.54) | ALDH1A1LMNAGAASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084178-B2 | Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-01 | — | — | US | disclosed |
| US-20050113442-A1 | Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives | BRISTOL-MYERS SQUIBB COMPANY | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113442-A1 | Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives | APP, PSEN1, PSEN2 | ALDH1A1 3997/4885LMNA 1191/4885GAA 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.