Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 2/20 | 0.55 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | KDM6B | O15054 | 1/20 | 0.55 |
| ▸ | TET3 | O43151 | 1/20 | 0.55 |
| ▸ | KDM4A | O75164 | 1/20 | 0.55 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KDM5A | P29375 | 1/20 | 0.55 |
| ▸ | ASPH | Q12797 | 1/20 | 0.55 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.55 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.55 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.55 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.55 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.55 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.55 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.55 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29830568 | 1.00 | KDM5C (0.55) | KDM5CKDM5BALDH1A1KDM4EKDM6B | |
| Hydrochloric Acid SCHEMBL28255645 | 0.98 | KDM5C (0.53) | KDM5CKDM5BALDH1A1KDM4EKDM6B | |
| SCHEMBL17712926 | 0.88 | KDM4E (0.74) | KDM5CKDM5BALDH1A1KDM4EKDM6B | |
| SCHEMBL7720509 | 0.88 | KDM5C (0.74) | KDM5CKDM5BALDH1A1KDM4EKDM6B | |
| Pyrrole SCHEMBL28266340 | 0.88 | KDM5C (0.44) | KDM5CKDM5BALDH1A1KDM4EKDM6B | |
| SCHEMBL19642219 | 0.88 | KDM5C (0.44) | KDM5CKDM5BALDH1A1KDM4EKDM6B | |
| SCHEMBL20285457 | 0.86 | ALDH1A1 (0.50) | KDM5CKDM5BALDH1A1KDM4EKDM6B | |
| SCHEMBL8061432 | 0.86 | ALDH1A1 (0.50) | KDM5CKDM5BALDH1A1KDM4EKDM6B | |
| SCHEMBL9561742 | 0.83 | KDM5C (0.47) | KDM5CKDM5BALDH1A1KDM4EKDM6B | |
| Phenylacetylene SCHEMBL19439259 | 0.82 | ALDH1A1 (0.44) | KDM5CKDM5BALDH1A1KDM4EKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153646-B | Pyridine dicarboxamide derivatives as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2022-08-02 | — | — | CN | claimed |
| CN-114249683-A | Synthesis method of N-hydroxyimide compound | 中国石化扬子石油化工有限公司 | 2022-03-29 | — | — | CN | claimed |
| CN-108884070-B | Pyridyl derivatives as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2021-07-02 | — | — | CN | claimed |
| CN-1649581-A | Substituted 3-amino-thieno [2, 3-b ] pyridine-2-carboxylic acid amide compounds, preparation method and uses thereof | BOEHRINGER INGELHEIM PHARMA (US) | 2005-08-03 | — | — | CN | claimed |
| WO-1998033786-A9 | ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS | — | 1998-12-30 | — | — | WO | claimed |
| US-5512586-A | FOR INHIBITING METABOLISM OF COLLAGEN; IMMUNOSUPPRESSANTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-04-30 | — | — | US | claimed |
| US-20230331715-A1 | SPIRO[3.3]HEPTANE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2023-10-19 | — | — | US | disclosed |
| US-20230278997-A1 | BICYCLO[1.1.1]PENTANE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2023-09-07 | — | — | US | disclosed |
| CN-109153646-B | Pyridine dicarboxamide derivatives as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2022-08-02 | — | — | CN | disclosed |
| WO-2022155419-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | ESCAPE Bio, Inc. (US) | 2022-07-21 | — | — | WO | disclosed |
| CN-114249683-A | Synthesis method of N-hydroxyimide compound | 中国石化扬子石油化工有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-108884070-B | Pyridyl derivatives as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2021-07-02 | — | — | CN | disclosed |
| US-10752640-B2 | Compounds active towards bromodomains | NUEVOLUTION A/S (DK) | 2020-08-25 | — | — | US | disclosed |
| US-5516901-A | Preparation of reactive phthalocyanine dyes | BASF AKTIENGESELLSCHAFT (DE) | 1996-05-14 | — | — | US | disclosed |
| US-5302708-A | Colorfastness | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-12 | — | — | US | disclosed |
| EP-0587137-A1 | Adsorbate comparised of an auxiliary agent mixture and a non-solid active agent for the manufacture of pharmaceutical preparations | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-16 | — | — | EP | disclosed |
| US-5260323-A | 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-09 | — | — | US | disclosed |
| US-5147553-A | Separation of fluid mixture | IONICS, INCORPORATED (US) | 1992-09-15 | — | — | US | disclosed |
| CN-1057649-A | 2,4-and 2,5-substituted pyridine-N-oxides, its preparation method and application | HOECHS AG (DE) | 1992-01-08 | — | — | CN | disclosed |
| US-4745187-A | Process for the preparation of water-soluble phthalocyanine dyestuffs | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230331715-A1 | SPIRO[3.3]HEPTANE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HAVCR2, NR1I3, NR1H4 | KDM5C 4224/4885KDM5B 4583/4885ALDH1A1 114/4885 |
| US-10752640-B2 | Compounds active towards bromodomains | BRD4, BRD3, BRDT | KDM5C 781/4885KDM5B 870/4885ALDH1A1 3848/4885 |
| US-20230278997-A1 | BICYCLO[1.1.1]PENTANE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HAVCR2, CYP1B1, CYP7A1 | KDM5C 2879/4885KDM5B 3228/4885ALDH1A1 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.