Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | MAX | P61244 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089535 | 0.89 | MKNK1 (0.50) | MKNK1MKNK2MAPK8MAPK10CAMKK2 | |
| SCHEMBL5089083 | 0.86 | MKNK1 (0.47) | MKNK1MKNK2MAPK8MAPK10CAMKK2 | |
| SCHEMBL5089224 | 0.84 | SMN1; SMN2 (0.53) | MKNK1MKNK2GSK3BPOLBSMN1; SMN2 | |
| SCHEMBL5091605 | 0.79 | MKNK1 (0.49) | MKNK1MKNK2GSK3BPIK3CGPOLB | |
| SCHEMBL5093713 | 0.78 | MKNK1 (0.47) | MKNK1MKNK2MAPK8POLBSMN1; SMN2 | |
| SCHEMBL5093386 | 0.78 | MKNK1 (0.53) | MKNK1MKNK2GSK3BPIK3CGPOLB | |
| SCHEMBL5095126 | 0.77 | MKNK1 (0.51) | MKNK1MKNK2MAPK8MAPK10GSK3B | |
| SCHEMBL7844058 | 0.77 | PIK3CG (0.56) | MAPK8MAPK10CAMKK2GSK3BPIK3CG | |
| SCHEMBL5089414 | 0.76 | MAPT (0.59) | MKNK1MKNK2MAPK8GSK3BPIK3CG | |
| SCHEMBL5091517 | 0.76 | MKNK1 (0.45) | MKNK1MKNK2GSK3BPIK3CGPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045519-B2 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2006-05-16 | — | — | US | disclosed |
| US-20020156087-A1 | Inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156087-A1 | Inhibitors of glycogen synthase kinase 3 | GSK3B, GSK3A, PYGB | MKNK1 142/4885MKNK2 345/4885MAPK8 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.