PYGB — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2844313	0.57	9/20
SCHEMBL3675624	0.34	9/20
SCHEMBL4313854	1.00	8/20
SCHEMBL4314468	1.00	8/20
SCHEMBL4309389	0.71	8/20
SCHEMBL4316291	0.61	8/20
SCHEMBL3232264	0.50	8/20
SCHEMBL2785358	0.43	8/20
SCHEMBL3711213	0.38	8/20
SCHEMBL4173060	1.00	7/20
SCHEMBL4182342	1.00	7/20
SCHEMBL4330413	1.00	7/20
SCHEMBL4173063	0.97	7/20
SCHEMBL4184772	0.97	7/20
SCHEMBL534896	0.78	7/20
SCHEMBL2059625	0.78	7/20
SCHEMBL2059641	0.78	7/20
SCHEMBL3792192	0.78	7/20
SCHEMBL3726095	0.70	7/20
SCHEMBL488948	0.70	7/20

Clinical trials — most relevant to PYGB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Lithium for Prevention of Cognitive Declining in Mood Illnesses	PHASE4	NOT_YET_RECRUITING
Lithium As a Treatment to Prevent Impairment of Cognition in Elders	PHASE4	COMPLETED
Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance.	PHASE2/PHASE3	ACTIVE_NOT_RECRUITING
Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla	PHASE2	COMPLETED
Triheptanoin Treatment Trial for Patients With Adult Polyglucosan Body Disease	PHASE2	COMPLETED
The Effect of Triheptanoin on Fatty Acid Oxidation and Exercise Tolerance in Patients With Glycogenoses	PHASE2	COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	PHASE2	RECRUITING
Safety and Efficacy of Liraglutide in Parkinson's Disease	PHASE2	COMPLETED
Development of NIC5-15 in the Treatment of Alzheimer's Disease	PHASE2	COMPLETED
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females	nan	COMPLETED
Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN Therapy	nan	COMPLETED
Relative Contribution of Brain Insulin Action for Postprandial Metabolism	nan	ACTIVE_NOT_RECRUITING
Evaluation of the Effect of Hypoglycemia With PET and a Norepinephrine Transporter Ligand	nan	COMPLETED
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging	nan	COMPLETED
Effect of Meal Timing in T2D on Hepatocytes SRIT1 and Clock Genes	nan	UNKNOWN
Effects of Sleep Hygiene Education and Progressive Relaxation Exercise on Anxiety, Sleep Quality and Glycemic Control in Diabetic Patients	nan	ENROLLING_BY_INVITATION
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
Frequency of Neonatal Hyperglycemia	nan	NOT_YET_RECRUITING
Investigation of Acute Physiological Effects of Aspiration Therapy	nan	COMPLETED
Can Erythropoietin Protect the Cerebral Blood Flow and Oxygenation During Simulated Dive?	nan	UNKNOWN
Mitigation of Type 2 Diabetes by Partial Ileal Bypass	nan	WITHDRAWN
WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)	nan	RECRUITING
Investigation Into the Effects Upon Brain Response to Change in Circulating Glucose Levels in Diabetes Mellitus	nan	COMPLETED
Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 Diabetics	nan	COMPLETED
Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo.	nan	COMPLETED
Effect of an Polyphenolic Beverage in Healthy Volunteers	nan	ACTIVE_NOT_RECRUITING
TBI Multimodal Monitoring Study	nan	UNKNOWN
PhosphoRus, Proton Imaging and Amyloid BuRdEn (PREPARE) ON AMYLOID BURDEN AND COGNITION	nan	COMPLETED
Utilizing Glycaemic Index: An Investigation of the Glycaemia and Cognition in Type 2 Diabetes	nan	COMPLETED
Safety Study of Repeated Doses of Glucagon on Animal Starch in the Liver	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PYGB binder may also engage these)

Protein	Name	Similarity
Q5R5M6	—	1.000	Q5R5M6 →
Q8CI94	—	1.000	Q8CI94 →
P79334	—	1.000	P79334 →
P53534	—	1.000	P53534 →
PYGL	Glycogen phosphorylase, liver form	1.000	landscape →
Q5MIB6	—	1.000	Q5MIB6 →
Q3B7M9	—	1.000	Q3B7M9 →
PYGM	Glycogen phosphorylase, muscle form	1.000	landscape →
O18751	—	1.000	O18751 →
P0AC87	—	1.000	P0AC87 →
P09811	—	1.000	P09811 →
P00489	—	1.000	P00489 →
Q8HXW4	—	1.000	Q8HXW4 →
P45180	—	1.000	P45180 →
Q0VCM4	—	1.000	Q0VCM4 →
Q5MIB5	—	1.000	Q5MIB5 →
P09812	—	1.000	P09812 →
Q9ET01	—	1.000	Q9ET01 →
Q9WUB3	—	1.000	Q9WUB3 →
O84250	—	0.999	O84250 →
P53537	—	0.998	P53537 →
Q9PKE6	—	0.998	Q9PKE6 →
Q9Z8N1	—	0.997	Q9Z8N1 →
Q00766	—	0.997	Q00766 →
P0AC86	—	0.997	P0AC86 →
Q9XTL9	—	0.996	Q9XTL9 →
P27472	—	0.996	P27472 →
P06738	—	0.995	P06738 →
P32811	—	0.995	P32811 →
Q9LKJ3	—	0.994	Q9LKJ3 →