Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | PAOX | Q6QHF9 | 4/20 | 0.65 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200627 | 1.00 | KDM4E (0.73) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL22984077 | 1.00 | KDM4E (0.73) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL25065006 | 0.98 | KDM4E (0.68) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL1525045 | 0.91 | KDM4E (0.64) | KDM4EMAPK1HIF1AADRA1APAOX | |
| Hexamethylenebisacetamide SCHEMBL9437043 | 0.88 | KDM4E (0.84) | KDM4EMAPK1HIF1AADRA1APAOX | |
| Trifluoroacetic Acid SCHEMBL27664340 | 0.87 | ADRA1A (0.59) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL14739904 | 0.85 | KDM4E (1.00) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL6516953 | 0.85 | KDM4E (1.00) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL14740196 | 0.85 | KDM4E (1.00) | KDM4EMAPK1HIF1AADRA1APAOX | |
| SCHEMBL1900654 | 0.85 | KDM4E (1.00) | KDM4EMAPK1HIF1AADRA1APAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059472-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2023164003-A2 | REAGENTS FOR LABELING BIOMOLECULES AND USES THEREOF | ULTIMA GENOMICS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| CN-116096869-A | Engineered enzymes and methods of making and using the same | 基因组股份公司 | 2023-05-09 | — | — | CN | disclosed |
| WO-2023288028-A2 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR | JANSSEN BIOTECH, INC. (US) | 2023-01-19 | — | — | WO | disclosed |
| CN-114341344-A | Engineered microorganisms and methods for improving aldehyde dehydrogenase activity | 基因组股份公司 | 2022-04-12 | — | — | CN | disclosed |
| US-10787505-B2 | Oligopeptide and methods for producing conjugates thereof | F. HOFFMANN-LA ROCHE AG (CH) | 2020-09-29 | — | — | US | disclosed |
| EP-1660507-B2 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | MILLENNIUM PHARM INC (US) | 2017-01-04 | — | — | EP | disclosed |
| US-9233115-B2 | Proteasome inhibitors and methods of using the same | MILLENNIUM PHARMACEUTICALS INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-20150057431-A1 | COMPOSITIONS FOR TREATING A DISEASE OR CONDITION ASSOCIATED WITH ABNORMAL ANGIOGENESIS | COVX TECHNOLOGIES IRELAND LTD (IE) | 2015-02-26 | — | — | US | disclosed |
| US-20140088042-A1 | Proteasome Inhibitors And Methods Of Using The Same | CEPHALON, INC. (US) | 2014-03-27 | — | — | US | disclosed |
| EP-1660507-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1658255-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2009014941-A1 | 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | SHENZEN CHIPSCREEN BIOSCIENCE, LTD. (CN) | 2009-01-29 | — | — | WO | disclosed |
| EP-1896086-A1 | HYDRAZIDE CONJUGATES AS IMAGING AGENTS | Bristol-Myers Squibb Pharma Company (US) | 2008-03-12 | — | — | EP | disclosed |
| US-7223745-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| WO-2007005491-A1 | HYDRAZIDE CONJUGATES AS IMAGING AGENTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-01-11 | — | — | WO | disclosed |
| EP-1658255-A2 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2006-05-24 | — | — | EP | disclosed |
| US-20050107307-A1 | Proteasome inhibitors and methods of using the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-19 | — | — | US | disclosed |
| US-20050059636-A1 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. | 2005-03-17 | — | — | US | disclosed |
| WO-2005016859-A2 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2005-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107307-A1 | Proteasome inhibitors and methods of using the same | PSMB11, PSMB5, PSMB6 | KDM4E 1703/4885MAPK1 1763/4885HIF1A 2005/4885 |
| US-20150057431-A1 | COMPOSITIONS FOR TREATING A DISEASE OR CONDITION ASSOCIATED WITH ABNORMAL ANGIOGENESIS | VEGFA, TIE1, TEK | KDM4E 3813/4885MAPK1 3878/4885HIF1A 31/4885 |
| US-20140088042-A1 | Proteasome Inhibitors And Methods Of Using The Same | PSMB11, PSMB5, PSMB6 | KDM4E 1703/4885MAPK1 1763/4885HIF1A 2005/4885 |
| US-10787505-B2 | Oligopeptide and methods for producing conjugates thereof | IAPP, APP, DNPEP | KDM4E 4679/4885MAPK1 4538/4885HIF1A 3037/4885 |
| US-20050059636-A1 | Proteasome inhibitors and methods of using the same | PSMB11, PSMB5, PSMB6 | KDM4E 1703/4885MAPK1 1763/4885HIF1A 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.