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SCHEMBL6086231

SCHEMBL6086231

CCN(c1ccc(C(=O)O)cc1)c1cc2c(cc1OCc1ccccc1)C(C)(C)CC=C2C(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 13/20 0.46
▸ RXRB P28702 10/20 0.46
▸ RXRG P48443 10/20 0.46
▸ PTGER1 P34995 2/20 0.39
▸ POLB P06746 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ THRB P10828 1/20 0.37
▸ HNF4A P41235 1/20 0.37
▸ MRGPRX4 Q96LA9 1/20 0.36
▸ NPC1 O15118 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6086107 0.92 RXRA (0.39) RXRARXRBRXRGMAPTNPC1
SCHEMBL6086640 0.89 RXRA (0.50) RXRARXRBRXRGPTGER1POLB
SCHEMBL6086311 0.86 RXRA (0.47) RXRARXRBRXRGPTGER1POLB
SCHEMBL6087434 0.83 RXRA (0.64) RXRARXRBRXRG
SCHEMBL6086851 0.82 RXRA (0.52) RXRARXRBRXRGPTGER1POLB
SCHEMBL6086188 0.82 RXRA (0.41) RXRARXRBRXRGHNF4AMRGPRX4
SCHEMBL6086018 0.81 RXRA (0.41) RXRARXRBRXRGMAPTNPC1
SCHEMBL6087992 0.81 RXRA (0.64) RXRARXRBRXRG
SCHEMBL6088054 0.80 RXRA (0.44) RXRARXRBRXRG
SCHEMBL6085507 0.79 RXRA (0.41) RXRARXRBRXRGMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7026487-B2 Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, a pyridyl group and an alkyl group, having retinoid-like biological activity ALLERGAN, INC. (US) 2006-04-11 — — US disclosed
US-20040097733-A1 Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity BEARD RICHARD L (US) 2004-05-20 — — US disclosed
US-20030166932-A1 Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity ALLERGAN SALES, INC. 2003-09-04 — — US disclosed
US-6613917-B1 Retinoid agonist, antagonist or negative hormone-like biological activity ALLERGAN, INC. 2003-09-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030166932-A1 Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity NR4A1, NR2E3, NR0B1 RXRA 13/4885RXRB 12/4885RXRG 17/4885
US-20040097733-A1 Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity NR4A1, NR2E3, NR0B1 RXRA 13/4885RXRB 12/4885RXRG 17/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.