Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.49 |
| ▸ | CCND1 | P24385 | 9/20 | 0.49 |
| ▸ | CDK2 | P24941 | 8/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.49 |
| ▸ | CDK1 | P06493 | 5/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.48 |
| ▸ | CCND3 | P30281 | 6/20 | 0.47 |
| ▸ | CCND2 | P30279 | 4/20 | 0.47 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090969 | 0.91 | CDK4 (0.46) | CDK4CCND1CDK2CCNA2CDK1 | |
| SCHEMBL6089773 | 0.87 | CDK4 (0.53) | CDK4CCND1CDK2CCNA2CDK1 | |
| SCHEMBL6087486 | 0.86 | ALK (0.56) | CDK4CCND1CDK2CCNE1SYK | |
| SCHEMBL6087151 | 0.85 | CDK4 (0.41) | CDK4CCND1CDK2CCNA2CDK1 | |
| SCHEMBL6088805 | 0.84 | CDK4 (0.51) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL6089242 | 0.84 | SYK (0.53) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL7468168 | 0.84 | CDK4 (0.40) | CDK4CCND1CDK2CCNA2CDK1 | |
| SCHEMBL7471665 | 0.83 | SYK (0.40) | CDK4CCND1CDK2CCNA2CDK1 | |
| SCHEMBL6089214 | 0.83 | CDK2 (0.54) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL6087827 | 0.82 | SYK (0.44) | CDK4CCND1CDK2CCNE1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |