Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.46 |
| ▸ | CCND1 | P24385 | 9/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CCND2 | P30279 | 3/20 | 0.42 |
| ▸ | CCND3 | P30281 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087196 | 0.91 | CDK4 (0.49) | CDK4CCND1CDK2CCNE1SYK | |
| SCHEMBL6087486 | 0.89 | ALK (0.56) | CDK4CCND1CDK2CCNE1SYK | |
| SCHEMBL6087151 | 0.87 | CDK4 (0.41) | CDK4CCND1CDK2CCNE1EGFR | |
| SCHEMBL6088805 | 0.87 | CDK4 (0.51) | CDK4CCND1CDK2CCNE1EGFR | |
| SCHEMBL6089242 | 0.86 | SYK (0.53) | CDK4CCND1CDK2CCNE1EGFR | |
| SCHEMBL7468168 | 0.86 | CDK4 (0.40) | CDK4CCND1CDK2CCNE1EGFR | |
| SCHEMBL6087469 | 0.86 | CDK4 (0.51) | CDK4CCND1CDK2CCNE1EGFR | |
| SCHEMBL6089214 | 0.86 | CDK2 (0.54) | CDK4CCND1CDK2CCNE1SYK | |
| SCHEMBL7471665 | 0.86 | SYK (0.40) | CDK4CCND1CDK2CCNE1EGFR | |
| SCHEMBL6087827 | 0.85 | SYK (0.44) | CDK4CCND1CDK2CCNE1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |