Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 | P05091 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.42 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | ACACA | Q13085 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087620 | 0.93 | ERN1 (0.43) | ALDH2MAOAMAOBERN1PTGS1 | |
| SCHEMBL6086350 | 0.93 | ALDH2 (0.43) | ALDH2MAOAMAOBERN1ALDH1A1 | |
| SCHEMBL6096490 | 0.91 | ALDH2 (0.47) | ALDH2MAOAMAOBMCL1ACACB | |
| SCHEMBL6087007 | 0.84 | MCL1 (0.53) | MAOBMCL1GAAMAPTPTGS1 | |
| SCHEMBL6088211 | 0.84 | MCL1 (0.50) | MAOBMCL1GAAMAPTMAPK1 | |
| SCHEMBL6088276 | 0.80 | SMN1; SMN2 (0.49) | KMT2AALDH1A1POLBMEN1NPC1 | |
| SCHEMBL22325682 | 0.74 | ALDH1A1 (0.54) | MCL1KMT2AALDH1A1POLBPTGS1 | |
| SCHEMBL29629324 | 0.74 | ALDH1A1 (0.54) | MCL1KMT2AALDH1A1POLBPTGS1 | |
| SCHEMBL6086911 | 0.74 | ESR2 (0.54) | MAOAMAOBKMT2AALDH1A1MEN1 | |
| SCHEMBL3119421 | 0.72 | CYP1A1 (0.43) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045628-B2 | Synthesis of 2-aryl-1-naphthol derivatives via a tandem palladium catalyzed arylation and dehydrogenation | ELI LILLY AND COMPANY (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040133047-A1 | Synthesis of 2-aryl-1-naphthol derivatives via a tandem palladium catalyzed arylation and dehydrogenation | MAY SCOTT ALLAN (US) | 2004-07-08 | — | — | US | disclosed |
| WO-2002044119-A2 | SYNTHESIS OF 2-ARYL-1-NAPHTHOL DERIVATIVES VIA A TANDEM PALLADIUM CATALYZED ARYLATION AND DEHYDROGENATION | ELI LILLY AND COMPANY (US) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040133047-A1 | Synthesis of 2-aryl-1-naphthol derivatives via a tandem palladium catalyzed arylation and dehydrogenation | NQO1, CYP1A1, DDT | ALDH2 275/4885MAOA 151/4885MAOB 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.