SCHEMBL6087320

SCHEMBL6087320

CC(C)c1c(O)ccc2cnc(Nc3ccc(N4CCC(CCCc5nnn[nH]5)CC4)c(F)c3)nc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 9/20 0.51
CCND1 P24385 7/20 0.51
CDK1 P06493 6/20 0.51
CCNB1 P14635 6/20 0.51
CCNE1 P24864 6/20 0.51
CDK2 P24941 6/20 0.51
JAK2 O60674 8/20 0.39
JAK3 P52333 7/20 0.39
JAK1 P23458 4/20 0.39
FLT3 P36888 4/20 0.39
CDK6 Q00534 2/20 0.39
CCND3 P30281 2/20 0.39
CYP1A2 P05177 1/20 0.39
LCK P06239 1/20 0.39
LYN P07948 1/20 0.39
CYP2C9 P11712 1/20 0.39
FLT1 P17948 1/20 0.39
TYK2 P29597 1/20 0.39
CYP2C19 P33261 1/20 0.39
FLT4 P35916 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6087157 0.90 CDK4 (0.65) CDK4CCND1CDK1CCNB1CCNE1
SCHEMBL6087876 0.89 CDK4 (0.65) CDK4CCND1CDK1CCNB1CCNE1
SCHEMBL6088082 0.83 CDK4 (0.67) CDK4CCND1CDK1CCNB1CCNE1
SCHEMBL6089263 0.82 CDK4 (0.51) CDK4CCND1CDK1CCNB1CCNE1
SCHEMBL6087345 0.79 CDK4 (0.77) CDK4CCND1CDK1CCNB1CCNE1
SCHEMBL6087550 0.78 CDK4 (0.63) CDK4CCND1CDK1CCNB1CCNE1
SCHEMBL6086805 0.77 CDK4 (0.58) CDK4CCND1CDK1CCNB1CCNE1
SCHEMBL6087523 0.76 CDK4 (0.49) CDK4CCND1CDK1CCNB1CCNE1
SCHEMBL6087344 0.73 CDK4 (0.48) CDK4CCND1CDK1CCNB1CCNE1
SCHEMBL6087488 0.73 CDK4 (0.65) CDK4CCND1CDK1CCNB1CCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1235815-A1 QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES WARNER-LAMBERT COMPANY (US) 2002-09-04 EP claimed
WO-2001038315-A1 QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES WARNER-LAMBERT COMPANY (US) 2001-05-31 WO claimed
US-6982260-B1 Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes WARNER-LAMBERT COMPANY (US) 2006-01-03 US disclosed
EP-1235815-A1 QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES WARNER-LAMBERT COMPANY (US) 2002-09-04 EP disclosed
WO-2001038315-A1 QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES WARNER-LAMBERT COMPANY (US) 2001-05-31 WO disclosed