Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 15/20 | 0.77 |
| ▸ | CCND1 | P24385 | 8/20 | 0.77 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.77 |
| ▸ | CDK2 | P24941 | 7/20 | 0.77 |
| ▸ | CDK1 | P06493 | 6/20 | 0.77 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.77 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.51 |
| ▸ | CSF1R | P07333 | 7/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | BRD4 | O60885 | 4/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | BRD2 | P25440 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.48 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086951 | 0.87 | CDK4 (1.00) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6088499 | 0.84 | CDK4 (0.75) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6086805 | 0.84 | CDK4 (0.58) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6086146 | 0.83 | CDK4 (1.00) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6087277 | 0.82 | CDK4 (0.68) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL23080459 | 0.80 | CDK4 (0.64) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL24386090 | 0.79 | CDK4 (0.64) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6089263 | 0.79 | CDK4 (0.51) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL22965051 | 0.79 | CDK4 (0.63) | CDK4CCND1CCNE1CDK2CDK1 | |
| SCHEMBL6087320 | 0.79 | CDK4 (0.51) | CDK4CCND1CCNE1CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | claimed |
| US-6982260-B1 | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes | WARNER-LAMBERT COMPANY (US) | 2006-01-03 | — | — | US | disclosed |