SCHEMBL6087664

SCHEMBL6087664

CC(C)CC(N)C(=O)N1CCNCC1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 4/20 0.44
DPP7 Q9UHL4 3/20 0.44
DPP8 Q6V1X1 2/20 0.44
DPP9 Q86TI2 1/20 0.44
SLC7A5 Q01650 1/20 0.44
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
HRH2 P25021 2/20 0.38
HRH1 P35367 2/20 0.38
ARG1 P05089 1/20 0.38
UBE2N P61088 1/20 0.38
CHRM5 P08912 1/20 0.38
CHRM3 P20309 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6087667 1.00 DPP4 (0.44) DPP4DPP7DPP8DPP9SLC7A5
Valeric Acid SCHEMBL28795453 0.86 HRH2 (0.43) DPP4DPP7DPP8DPP9SLC7A5
SCHEMBL1707036 0.83 DPP7 (0.51) DPP4DPP7DPP8DPP9SLC7A5
SCHEMBL7817249 0.83 DPP7 (0.51) DPP4DPP7DPP8DPP9SLC7A5
SCHEMBL1707035 0.83 DPP7 (0.51) DPP4DPP7DPP8DPP9SLC7A5
SCHEMBL18774974 0.81 MMP1 (0.51) DPP4DPP7DPP8DPP9SLC7A5
Hydrochloric Acid SCHEMBL11172704 0.81 DPP7 (0.50) DPP4DPP7DPP8DPP9SLC7A5
SCHEMBL1622976 0.80 MMP1 (0.40) CA12CA1CA2CA9UBE2N
SCHEMBL1622973 0.80 MMP1 (0.40) CA12CA1CA2CA9UBE2N
SCHEMBL20413342 0.80 DPP4 (0.45) DPP4DPP7DPP8DPP9SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6982260-B1 Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes WARNER-LAMBERT COMPANY (US) 2006-01-03 US disclosed
EP-1235815-A1 QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES WARNER-LAMBERT COMPANY (US) 2002-09-04 EP disclosed
EP-0877614-B1 METHOD FOR INDUCING DEATH OF NEOPLASTIC CELLS USING PIPERAZINE OXIRANE DERIVATIVES HITACHI CHEMICAL CO LTD (JP) 2002-06-26 EP disclosed
WO-2001038315-A1 QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES WARNER-LAMBERT COMPANY (US) 2001-05-31 WO disclosed
US-6054437-A Method for inducing death of neoplastic cells using piperazine derivatives HITACHI CHEMICAL RESEARCH CENTER, INC. (US) 2000-04-25 US disclosed
US-5859013-A ADMINISTERING TO TREAT MULTIDRUG RESISTANT CANCERS HITACHI CHEMICAL CO., LTD. (JP) 1999-01-12 US disclosed
EP-0877614-A1 METHOD FOR INDUCING DEATH OF NEOPLASTIC CELLS USING PIPERAZINE OXIRANE DERIVATIVES HITACHI CHEMICAL COMPANY, LTD. (JP) 1998-11-18 EP disclosed
US-5733911-A ANTITUMOR AGENTS AND ANTICARCINOGENIC AGENTS HITACHI CHEMICAL CO., LTD. (JP) 1998-03-31 US disclosed
WO-1997026881-A1 METHOD FOR INDUCING DEATH OF NEOPLASTIC CELLS USING PIPERAZINE OXIRANE DERIVATIVES HITACHI CHEMICAL CO., LTD. (JP) 1997-07-31 WO disclosed
US-4596803-A Treating myocardial infarction NIPPON CHEMIPHAR CO., LTD. (JP) 1986-06-24 US disclosed
US-4507297-A MYOCARDIAL INFARCTION NIPPON CHEMIPHAR CO., LTD. (JP) 1985-03-26 US disclosed