Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088431 | 0.88 | CYSLTR1 (0.56) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL6088572 | 0.80 | MAPT (0.44) | MAPTHTTSMN1; SMN2CYSLTR1GPBAR1 | |
| SCHEMBL10546039 | 0.78 | CYSLTR1 (0.66) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL6089615 | 0.77 | ABCB1 (0.46) | MAPTHTTSMN1; SMN2MAOBNPC1 | |
| SCHEMBL6089044 | 0.76 | DHODH (0.38) | MAPTHTTSMN1; SMN2CYSLTR1GPBAR1 | |
| SCHEMBL6088343 | 0.76 | MAPT (0.41) | MAPTHTTSMN1; SMN2CYSLTR1GPBAR1 | |
| SCHEMBL6090607 | 0.74 | MAPT (0.46) | MAPTHTTSMN1; SMN2CYSLTR1GPBAR1 | |
| SCHEMBL6089419 | 0.73 | CYSLTR1 (0.44) | MAPTHTTSMN1; SMN2CYSLTR1CYSLTR2 | |
| SCHEMBL10544867 | 0.73 | CYSLTR1 (0.75) | MAPTSMN1; SMN2CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10547803 | 0.73 | CYSLTR1 (0.69) | CYSLTR1GPBAR1CYSLTR2PDE10AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |