Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088031 | 1.00 | PDGFRB (0.48) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6091151 | 0.90 | ABL1 (0.57) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6091157 | 0.90 | ABL1 (0.57) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6088733 | 0.88 | PDGFRB (0.43) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6088738 | 0.88 | PDGFRB (0.43) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6087845 | 0.87 | PDGFRB (0.43) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6099515 | 0.87 | PDGFRB (0.43) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6087837 | 0.87 | PDGFRB (0.43) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6092844 | 0.84 | PDGFRB (0.41) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6092846 | 0.84 | PDGFRB (0.41) | PDGFRBFGFR1ABL1RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |