Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 9/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092846 | 1.00 | PDGFRB (0.41) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6092402 | 0.85 | FLT3 (0.45) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6092395 | 0.85 | FLT3 (0.45) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6091151 | 0.84 | ABL1 (0.57) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6091157 | 0.84 | ABL1 (0.57) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6088031 | 0.84 | PDGFRB (0.48) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6088027 | 0.84 | PDGFRB (0.48) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6090821 | 0.83 | KDR (0.55) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6090825 | 0.83 | KDR (0.55) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6091983 | 0.81 | CHEK1 (0.47) | PDGFRBFGFR1ALKRETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |